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Homocarnosine

CAT: 0804-HY-114883Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114883Size:1 Each
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Description
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1].Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2].
CAS Number
3650-73-5
Product Name Alternative
L-Homocarnosine
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Endogenous Metabolite; GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/homocarnosine.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC(CCCN)=O)CC1=CNC=N1)O
Molecular Formula
C10H16N4O3
Molecular Weight
240.26
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]O A Petroff, et al. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998 Dec;44 (6) :948-52.|[2]Thanutchaporn Kumrungsee, et al. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles. Amino Acids. 2020 May;52 (5) :743-753.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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MBS5781680Homocarnosine
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T73818-01Homocarnosine TFA

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