PROTAC Bcl2 degrader-1

PROTAC Bcl2 degrader-1

• CAS Number: 2378801-85-3
• UNSPSC Description: PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1] (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).
• Target Antigen: Bcl-2 Family; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bcl2-in-1.html
• Purity: 99.80
• Solubility: DMSO : 25 mg/mL (ultrasonic)
• Smiles: O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O
• Molecular Weight: 941.84
• References & Citations: [1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported