PROTAC Hsp90α degrader 1

PROTAC Hsp90α degrader 1

• CAS Number: 3031078-90-4
• UNSPSC Description: PROTAC Hsp90α degrader 1 (Compound X10g) is a selective PROTAC Hsp90α degrader. PROTAC Hsp90α degrader 1 can be used for breast cancer research. PROTAC Hsp90α degrader 1 inhibits the proliferation of MDA-MB-231, MDA-MB-468, MCF-7, MX-1 cells with IC50s of 51.48 μM, 16.46 μM, 8.93 μM, 11.95 μM respectively[1].
• Target Antigen: HSP; PROTACs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-hsp90α-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: OC1=CC=C(C(N2CC3=CC=C(CN4CCN(CCCCCCC(NC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CC4)C=C3C2)=O)C=C1C(C)C
• Molecular Weight: 762.89
• References & Citations: [1]Jiang Q, et al. Discovery of X10g as a selective PROTAC degrader of Hsp90α protein for treating breast cancer. Eur J Med Chem. 2023 Jul 28;260:115690.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported