CDK8/19-IN-2

CDK8/19-IN-2

• CAS Number: 3024381-54-9
• UNSPSC Description: CDK8/19-IN-2 (compound 12) is an orally active and potent cyclin-dependent kinase 8/19 (CDK8 and CDK19) inhibitor, with IC50 values of 2.08 and 2.49 nM, respectively. CDK8/19-IN-2 can be used for acute myeloid leukemia (AML), breast cancer, and lymphoma research[1].
• Target Antigen: CDK; STAT
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;JAK/STAT Signaling;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk8-19-in-2.html
• Smiles: BrC1=C(C=C2N(C(N3CCNCC3)=NC2=C1C(F)F)C4CCOCC4)Br
• Molecular Weight: 494.17
• References & Citations: [1]Xu J, et al. Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer. J Med Chem. 2024 May 23;67(10):8161-8171.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported