CDK8-IN-1

• UNSPSC Description:

  CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

• Target Antigen:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CDK8-IN-1.html

• Purity:

  99.77

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC(C1=C(C(F)(F)F)C(C2=CC=NC=C2)=CN1)=O

• Molecular Weight:

  255.20

• References & Citations:

  [1]Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1629633-48-2