CDK8-IN-1

• Description :

  CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

• UNSPSC :

  12352005

• Target :

  CDK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/CDK8-IN-1.html

• Purity :

  99.77

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  NC(C1=C(C(F)(F)F)C(C2=CC=NC=C2)=CN1)=O

• Molecular Formula :

  C11H8F3N3O

• Molecular Weight :

  255.20

• References & Citations :

  [1]Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27 (18) :4488-4492.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK8

• CAS Number :

  [1629633-48-2]