CDK8/19-IN-3

• Description:

  CDK8/19-IN-3 (compound 3-7) is a potent and selective CDK8 and CDK19 inhibitor. CDK8/19-IN-3 upregulates IL-10 levels. CDK8/19-IN-3 has the potential for the research of inflammatory bowel disease (IBD) [1].

• UNSPSC:

  12352005

• Target:

  CDK

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Inflammation/Immunology

• Smiles:

  N#CC1=CC (C (N2C[C@@H] (C3=NC (N4C[C@H] (F) CC4) =NC=C3) C[C@@H] (OC) C2) =O) =CN1

• Molecular Formula:

  C20H23FN6O2

• Molecular Weight:

  398.43

• References & Citations:

  [1]Nicolle S, et al. Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors. J Med Chem. 2025 Jan 8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK19; CDK8