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CDK8-IN-11

CAT: 0804-HY-151463-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-151463-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK8-IN-11 is a potent and selective CDK8 inhibitor with an IC50 value of 46 nM. CDK8-IN-11 inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 can be used in the research of colon cancer[1].
CAS Number
2839338-28-0
UNSPSC
12352005
Target
CDK; Wnt; β-catenin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-in-11.html
Purity
98.20
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(OC3=CC=C(N)N=C3)C=C2
Molecular Formula
C19H15F3N4O2
Molecular Weight
388.34
References & Citations
[1]Yao Yao Yan, et al. Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy. J Med Chem. 2022 Sep 20.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8

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