CGP 36742

• Description :

  CGP 36742 (SGS-742) is an orally active and selective antagonist of GABAB receptor (IC50 = 36 µM) . CGP 36742 is a blood-brain barrier (BBB) penetrant compound and improves cognitive performances. CGP 36742 can be used for depression study[1][2][3][4].

• Product Name Alternative :

  SGS-742

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H319

• Target :

  GABA Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cgp-36742.html

• Purity :

  98.0

• Solubility :

  H2O : 125 mg/mL (ultrasonic)

• Smiles :

  O=P(CCCN)(O)CCCC

• Molecular Formula :

  C7H18NO2P

• Molecular Weight :

  179.20

• Precautions :

  H302, H319

• References & Citations :

  [1]Nowak G, et al. Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br J Pharmacol. 2006 Nov;149 (5) :581-90.|[2]Olpe HR, et al. The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro. Eur J Pharmacol. 1993 Mar 23;233 (2-3) :179-86.|[3]Andrén PE, et al. Blood-brain barrier penetration of 3-aminopropyl-n-butylphosphinic acid (CGP 36742) in rat brain by microdialysis/mass spectrometry. J Mass Spectrom. 1998 Mar;33 (3) :281-7. |[4]Pittaluga A, et al. Potentiation of NMDA receptor function through somatostatin release: a possible mechanism for the cognition-enhancing activity of GABA (B) receptor antagonists. Neuropharmacology. 2001 Sep;41 (3) :301-10.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [123690-78-8]