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CGP-49823

CAT: 0804-HY-19203Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-19203Size: 1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGP-49823 is an orally active and highly selective antagonist of the neurokinin 1 receptor (NK1 receptor) . CGP-49823‘s potency is significantly higher in isolated spinal cords of hamsters than in those of rats. CGP 49823 exhibits a significant anti-anxiety effect in social interaction experiments of rats, and its tolerance develops slowly, without causing anxiety-like withdrawal reactions after discontinuation. CGP-49823 can be used in anxiety and depression research[1][2].
CAS Number
[150705-88-7]
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(N1[C@H](CC2=CC=CC=C2)C[C@@H](NCC3=CC=NC4=CC=CC=C34)CC1)C5=CC(C)=CC(C)=C5
Molecular Formula
C31H33N3O
Molecular Weight
463.61
References & Citations
[1]File SE. Anxiolytic action of a neurokinin1 receptor antagonist in the social interaction test. Pharmacol Biochem Behav. 1997 Nov;58 (3) :747-52.|[2]Pozza MF, et al. The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro. Eur J Pharmacol. 1998 Jan 26;342 (2-3) :203-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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