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CGP-42112

CAT: 0804-HY-12405-01Size: 1 mgDry Ice: NoHazardous: No
HY-12405-011 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGP-42112 (CGP-42112A) is a potent Angiotensin-II subtype 2 receptor (AT2 R) agonist[1].
CAS Number
[127060-75-7]
Product Name Alternative
CGP42112A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/CGP-42112.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC[C@H](C)[C@@H](C(O)=O)NC([C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H](CCCCNC([C@H](CCCNC(N)=N)NC(OCC3=CC=CC=C3)=O)=O)NC([C@H](CC4=CC=C(C=C4)O)NC(C5=CC=CN=C5)=O)=O)=O)=O)CCC1)=O
Molecular Formula
C52H69N13O11
Molecular Weight
1052.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Takekoshi K, et al. Angiotensin-II subtype 2 receptor agonist (CGP-42112) inhibits catecholamine biosynthesis in cultured porcine adrenal medullary chromaffin cells. Biochem Biophys Res Commun. 2000 Jun 7;272 (2) :544-50.|[2]Speth RC. [125I]CGP 42112 binding reveals differences between rat brain and adrenal AT2 receptor binding sites. Regul Pept. 1993 Mar 19;44 (2) :189-97.|[3]Naveri L, et al. Angiotensin II AT2 receptor stimulation extends the upper limit of cerebral blood flow autoregulation: agonist effects of CGP 42112 and PD 123319. J Cereb Blood Flow Metab. 1994 Jan;14 (1) :38-44.|[4]Heemskerk FM, et al. Quantitative autoradiography of angiotensin II AT2 receptors with [125I]CGP 42112. Brain Res. 1995 Apr 17;677 (1) :29-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor; AT2 Receptor

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