PROTAC ERα Degrader-6

PROTAC ERα Degrader-6

• UNSPSC Description: PROTAC ERα Degrader-6 (compound A2) is a potent PROTAC degrader of ERα, with IC50 of 0.11 μM in MCE-7 cells. PROTAC ERα Degrader-6 has anti-tumor effect. PROTAC ERα Degrader-6 is a fluorescent probes with Em of 582 nm that enable real-time visualization of ERα protein degradation[1].
• Target Antigen: Estrogen Receptor/ERR; PROTACs
• Type: Reference compound
• Related Pathways: PROTAC;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-erα-degrader-6.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C(N1C[C@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@@H](NC(CCCCCCCOC4=C(C=CC(O)=C4)/C=C/C5=C/C(C6=CC(O)=CC=C6O5)=C(C#N)/C#N)=O)C(C)(C)C
• Molecular Weight: 913.09
• References & Citations: [1]Xiaohua Wang, et al. Fluorescence theranostic PROTACs for real-time visualization of ERα degradation. Eur J Med Chem. 2024 Feb 1:267:116184.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported