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Pan-KRAS-IN-7

CAT: 0804-HY-162440Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162440Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pan-KRAS-IN-7 (Compound 25) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC50 of 0.35 and 0.51 nM, respectively[1].
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-7.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1N(CC#CC2=C[C@]([C@]3=C(CC(C)(C)COC4=O)C5=CC(C6=CSC(C[C@H](NC([C@H]7[C@H](C)[C@@H]7C)=O)C(N8CCC[C@@H]4N8)=O)=N6)=CC=C5N3CC)=C([C@H](C)OC)N=C2)CCOC1
Molecular Formula
C48H61N7O7S
Molecular Weight
880.11
References & Citations
[1]Chen YF, et al., Pan-kras inhibitor compound. WO2024060966A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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