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Pan-KRAS-IN-4

CAT: 0804-HY-156528Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156528Size:1 Each
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Description
Pan-KRAS-IN-4 (compound 5) is a potent inhibitor of KRAS with IC50s of 0.37 nM (Kras G12C), 0.19 nM (Kras G12V), respectively[1].
CAS Number
2885961-55-5
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-4.html
Solubility
10 mM in DMSO
Smiles
C=CC(N1[C@@]2([H])CN(C3=C(C=NC(C4=C5C(C#C)=C(F)C=CC5=CC(O)=C4)=C6F)C6=NC(OCC78CCCN7CCC8)=N3)C[C@]1([H])CC2)=O
Molecular Formula
C36H34F2N6O3
Molecular Weight
636.69
References & Citations
[1]Chen Y, et al. Synthesis of Mutant KRAS modulators treating neoplastic, autoimmune diseases, and inflammatory disorders. World Intellectual Property Organization, WO2022271823 A1 2022-12-29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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