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Pan-KRAS-IN-2

CAT: 0931-T79800-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79800-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2882825-14-9
Target
Ras
Related Pathways
MAPK, GPCR/G Protein
Bioactivity
Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly reduced inhibition, with an IC50 >10 μM, for the KRAS G13D mutant [1].
Smiles
C(OC=1N=C(C2=C(N1)C(C)=C(C=C2)C=3C4=C(C=C(O)C3)C=CC(F)=C4C#C)N5CCCOCC5)[C@@]67N(C[C@H](F)C6)CCC7
Molecular Formula
C34H34F2N4O3
Molecular Weight
584.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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