Nav1.8-IN-2

CAT: 0804-HY-143481-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-143481-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nav1.8-IN-2 (compound 35A) is a potent Nav1.8 inhibitor with an IC50 value of 0.4 nM. Nav1.8-IN-2 can be used for researching pain disorders, cough disorders, and acute and chronic itch disorders[1].
CAS Number
[2756250-30-1]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav1-8-in-2.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1OC(NC1)=O)N[C@@H](C2=CC=C(C=C2)Cl)C3=CC(C(F)(F)F)=C(C=C3)Cl
Molecular Formula
C18H13Cl2F3N2O3
Molecular Weight
433.21
References & Citations
[1]Sabnis RW. 2-Oxooxazolidine-5-carboxamides as Nav1.8 Inhibitors for Treating Pain Disorders, Cough Disorders, and Acute and Chronic Itch Disorders. ACS Med Chem Lett. 2022;13 (3) :334-335. Published 2022 Mar 1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.8

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