ZY-444

• Description :

  ZY-444 is an anti-cancer agent, targeting pyruvate carboxylase (PC) . ZY-444 suppresses the Wnt/β-catenin/Snail signaling pathway by blocking nuclear translocation of β-catenin. ZY-444 selectively inhibits proliferation, migration, and invasion and induces apoptosis in cancer cells. ZY-444 exhibits potent anti-tumor in cancer mouse models. ZY-444 can be used for the study of breast cancer, lung cancer (NSCLC), prostate cancer and iodine-refractory thyroid cancer[1][2][3].

• UNSPSC :

  12352005

• Target :

  Apoptosis; ERK; Pyruvate Carboxylase (PC) ; Wnt; β-catenin

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/zy-444.html

• Purity :

  99.51

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C)CNC1=NC=CC(NCC2=CC=C(C3=CC=C(OCC4=CC=CC=C4)C=C3)S2)=N1

• Molecular Formula :

  C26H28N4OS

• Molecular Weight :

  444.59

• References & Citations :

  [1]Lin Q, et al. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. Adv Sci (Weinh) . 2020 Mar 12;7 (9) :1903483.|[2]Liu Y, et al. Pyruvate carboxylase promotes malignant transformation of papillary thyroid carcinoma and reduces iodine uptake. Cell Death Discov. 2022 Oct 20;8 (1) :423. |[3]Han MT, et al. ZY-444 inhibits the growth and metastasis of prostate cancer by targeting TNFAIP3 through TNF signaling pathway. Am J Cancer Res. 2023 Apr 15;13 (4) :1533-1546.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1802650-31-2]