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ZY-444

CAT: 0804-HY-142870-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-142870-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZY-444 is an anti-cancer agent, targeting pyruvate carboxylase (PC) . ZY-444 suppresses the Wnt/β-catenin/Snail signaling pathway by blocking nuclear translocation of β-catenin. ZY-444 selectively inhibits proliferation, migration, and invasion and induces apoptosis in cancer cells. ZY-444 exhibits potent anti-tumor in cancer mouse models. ZY-444 can be used for the study of breast cancer, lung cancer (NSCLC), prostate cancer and iodine-refractory thyroid cancer[1][2][3].
CAS Number
1802650-31-2
UNSPSC
12352005
Target
Apoptosis; ERK; Pyruvate Carboxylase (PC) ; Wnt; β-catenin
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zy-444.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)CNC1=NC=CC(NCC2=CC=C(C3=CC=C(OCC4=CC=CC=C4)C=C3)S2)=N1
Molecular Formula
C26H28N4OS
Molecular Weight
444.59
References & Citations
[1]Lin Q, et al. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. Adv Sci (Weinh) . 2020 Mar 12;7 (9) :1903483.|[2]Liu Y, et al. Pyruvate carboxylase promotes malignant transformation of papillary thyroid carcinoma and reduces iodine uptake. Cell Death Discov. 2022 Oct 20;8 (1) :423. |[3]Han MT, et al. ZY-444 inhibits the growth and metastasis of prostate cancer by targeting TNFAIP3 through TNF signaling pathway. Am J Cancer Res. 2023 Apr 15;13 (4) :1533-1546.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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