MS-444

• UNSPSC Description:

  MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM.

• Target Antigen:

  Myosin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MS-444.html

• Purity:

  99.45

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|N-Methylpyrrolidone (NMP) : 20 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C(C)OC=C1C2)C3=C2C(O)=CC=C3O

• Molecular Weight:

  230.22

• References & Citations:

  [1]Satoshi Nakanishi. et al. MS-444, a new inhibitor of myosin light chain kinase from Micromonosporasp.KY7123. The Journal Of Antibiotics. 1995,48(9):948-951.|[2]Fernando F. Blanco.et al, Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. Oncotarget. 2016 Nov 8; 7(45): 74043-74058.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  150045-18-4