CM-444

• Target:

  DNA Methyltransferase|||HDAC

• Related Pathways:

  Chromatin/Epigenetic|||DNA Damage/DNA Repair

• Bioactivity:

  CM-444 is an inhibitor of HDAC (IC50 ranging from 6 nM to 0.6 ?M) and DNA methyltransferase (DNMT, IC50 ranging from 1.8 to 2.3 ?M) . This compound induces differentiation in acute myeloid leukemia cells, exhibits anti-leukemia activity, and enhances survival rates in mouse models.

• Molecular Formula:

  C27H30N6O5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C