HC-5404-Fu

HC-5404-Fu

• CAS Number: 3034479-99-4
• UNSPSC Description: HC-5404-Fu is a PERK inhibitor with an antitumor activity. HC-5404-Fu inhibits endoplasmic reticulum stress response signalling. HC-5404-Fu sensitizes renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). HC-5404-Fu is promising for research of renal cell carcinoma, gastric cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors[1][2][3].
• Target Antigen: PERK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hc-5404-fu.html
• Smiles: CC(C)NC(C1=CC(C2=CC=C(C=C2C)NC([C@@H](C3=CC(F)=CC(F)=C3)O)=O)=CN=C1N)=O.O=C(O)/C=C/C(O)=O.[1/2]
• Molecular Weight: 512.51
• References & Citations: [1]Lines CL, et al. The integrated stress response in cancer progression: a force for plasticity and resistance. Front Oncol. 2023 Aug 3;13:1206561. |[2]Al-Rawi DH, et al. Targeting chromosomal instability in patients with cancer. Nat Rev Clin Oncol. 2024 Sep;21(9):645-659.|[3]Al Azzani M, et al. Phytochemical-mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach. Phytother Res. 2024 Jul 3.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 1