HC-7366

• Description:

  HC-7366 (GCN2 modulator-1) is an orally effective GCN2 activator. HC-7366 can effectively compete and occupy the ATP binding pocket of GCN2, with its IC50 being 72 nM. This binding triggers the conformational activation of GCN2, leading to the upregulation of downstream signals (such as ATF4, ASNS) in the integrated stress response (ISR) pathway, ultimately exerting anti-tumor effects. HC-7366 also has inhibitory activity against ZAK, with its IC50 being 47 nM. HC-7366 can be used for research on fibrosarcoma and acute myeloid leukemia[1].

• Product Name Alternative:

  GCN2 modulator-1

• UNSPSC:

  12352005

• Target:

  Eukaryotic Initiation Factor (eIF)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hc-7366.html

• Purity:

  99.95

• Solubility:

  DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (C1=C2C=NC (C3=C (C=CC (NS (=O) (C4=CC (Cl) =CN=C4OC) =O) =C3F) F) =CN2C=N1) NC

• Molecular Formula:

  C20H15ClF2N6O4S

• Molecular Weight:

  508.89

• References & Citations:

  [1]Thomson CG, et al. Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator. J Med Chem. 2024 Apr 11;67 (7) :5259-5271.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  2803470-63-3