HC-258

• UNSPSC Description:

  HC-258 (compound 26) binds with the cysteine in TEAD’s PA pocket. HC-258 reduces the CTGF, CYR61, AXL, and NF2 transcript levels and inhibits the migration of MDA-MB-231 breast cancer cells[1].

• Target Antigen:

  YAP

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hc-258.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C=CC(NC1=CC=CC(NC2=CC=CC(OCCCCC)=C2)=C1)=O

• Molecular Weight:

  324.42

• References & Citations:

  [1]Ahmed Fnaiche, et al. Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. ACS Med. Chem. Lett. 2023, 14, 12.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported