HC-258

HC-258

• UNSPSC Description: HC-258 (compound 26) binds with the cysteine in TEAD’s PA pocket. HC-258 reduces the CTGF, CYR61, AXL, and NF2 transcript levels and inhibits the migration of MDA-MB-231 breast cancer cells[1].
• Target Antigen: YAP
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hc-258.html
• Solubility: 10 mM in DMSO
• Smiles: C=CC(NC1=CC=CC(NC2=CC=CC(OCCCCC)=C2)=C1)=O
• Molecular Weight: 324.42
• References & Citations: [1]Ahmed Fnaiche, et al. Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. ACS Med. Chem. Lett. 2023, 14, 12.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported