HC-258

• Description :

  HC-258 (compound 26) binds with the cysteine in TEAD’s PA pocket. HC-258 reduces the CTGF, CYR61, AXL, and NF2 transcript levels and inhibits the migration of MDA-MB-231 breast cancer cells[1].

• UNSPSC :

  12352005

• Target :

  YAP

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hc-258.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C=CC(NC1=CC=CC(NC2=CC=CC(OCCCCC)=C2)=C1)=O

• Molecular Formula :

  C20H24N2O2

• Molecular Weight :

  324.42

• References & Citations :

  [1]Ahmed Fnaiche, et al. Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. ACS Med. Chem. Lett. 2023, 14, 12.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3056128-12-9]