HC-070

CAT: 0804-HY-112302-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112302-01Size:1 mg
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Description
HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively.
CAS Number
[1628291-95-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/HC-070.html
Purity
99.74
Solubility
DMSO : ≥ 62.5 mg/mL
Smiles
O=C(N1CCCO)N(C)C2=C(N(CC3=CC=C(Cl)C=C3)C(OC4=CC=CC(Cl)=C4)=N2)C1=O
Molecular Formula
C22H20Cl2N4O4
Molecular Weight
475.32
Precautions
H302, H315, H319
References & Citations
[1]Just S, et al. Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One. 2018 Jan 31;13 (1) :e0191225.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS5754950HC-070
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A19515-5HC-070 5mg
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