MI 63

• Description :

  MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM) . MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS[1].

• UNSPSC :

  12352005

• Target :

  MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mi-63.html

• Smiles :

  O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)NCCN5CCOCC5

• Molecular Formula :

  C29H35Cl2FN4O3

• Molecular Weight :

  577.52

• References & Citations :

  [1]Canner JA, et al., MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53. Br J Cancer. 2009 Sep 1;101 (5) :774-81.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [908027-21-4]