Nutlin 1

• UNSPSC Description:

  Nutlin 1, an antagonist of MDM2, activates a major cellular function of the p53 pathway, with an IC50 value of 0.26 μM[1].

• Target Antigen:

  MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nutlin-1.html

• Smiles:

  CC(N1CCN(CC1)C(N2[C@H]([C@H](N=C2C3=CC=C(C=C3OC(C)C)OC)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl)=O)=O

• Molecular Weight:

  609.54

• References & Citations:

  [1]Lyubomir T Vassilev, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303(5659):844-8.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  548472-58-8