Nutlin 1

• Description :

  Nutlin 1, an antagonist of MDM2, activates a major cellular function of the p53 pathway, with an IC50 value of 0.26 μM[1].

• CAS Number :

  [548472-58-8]

• UNSPSC :

  12352005

• Target :

  MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nutlin-1.html

• Smiles :

  CC(N1CCN(CC1)C(N2[C@H]([C@H](N=C2C3=CC=C(C=C3OC(C)C)OC)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl)=O)=O

• Molecular Formula :

  C32H34Cl2N4O4

• Molecular Weight :

  609.54

• References & Citations :

  [1]Lyubomir T Vassilev, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303 (5659) :844-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported