(Rac)-Nutlin-3

• UNSPSC Description:

  (Rac)-Nutlin-3 (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). (Rac)-Nutlin-3 inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. (Rac)-Nutlin-3 has the potential for the study of TP53 wild-type ovarian carcinomas[1][2].

• Target Antigen:

  Apoptosis; Autophagy; E1/E2/E3 Enzyme; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rac-nutlin-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=NC(C3=CC=C(C=C3)Cl)C1C4=CC=C(C=C4)Cl)N5CC(NCC5)=O

• Molecular Weight:

  581.49

• References & Citations:

  [1]Crane EK, et al. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015 Aug 6;10(8):e0135101.|[2]Tovar C, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93.|[3]M Ulrich, et al. Murine tumor models for the in vivo evaluation of natural compounds and their derivatives as new cancer therapeutics. München. 2016.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  890090-75-2