(Rac) -Nutlin-3

• Description :

  (Rac) -Nutlin-3 (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM) . (Rac) -Nutlin-3 inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. (Rac) -Nutlin-3 has the potential for the study of TP53 wild-type ovarian carcinomas[1][2].

• Product Name Alternative :

  (Rac) -Rebemadlin

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Apoptosis; Autophagy; E1/E2/E3 Enzyme; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rac-nutlin-3.html

• Purity :

  98.18

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=NC(C3=CC=C(C=C3)Cl)C1C4=CC=C(C=C4)Cl)N5CC(NCC5)=O

• Molecular Formula :

  C30H30Cl2N4O4

• Molecular Weight :

  581.49

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Crane EK, et al. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015 Aug 6;10 (8) :e0135101.|[2]Tovar C, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006 Feb 7;103 (6) :1888-93.|[3]M Ulrich, et al. Murine tumor models for the in vivo evaluation of natural compounds and their derivatives as new cancer therapeutics. München. 2016.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [890090-75-2]