Nutlin-3

• Description :

  Nutlin-3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  E1/E2/E3 Enzyme; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Nutlin-3.html

• Purity :

  99.18

• Solubility :

  DMSO : ≥ 50 mg/mL|Ethanol : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1NCCN(C(N2[C@@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1

• Molecular Formula :

  C30H30Cl2N4O4

• Molecular Weight :

  581.49

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Yu Z, et al. Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors. Int J Mol Sci. 2014 Sep 5;15 (9) :15741-53.|[2]Zhang Y, et al. Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth.Cancer Biol Ther. Cancer Biol Ther. 2012 Aug;13 (10) :915-24.|[3]Supiot S, et al. Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53. Mol Cancer Ther. 2008 Apr;7 (4) :993-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [548472-68-0]