Nutlin-3a (Standard)

• Description:

  Nutlin-3a (Standard) is the analytical standard of Nutlin-3a (HY-10029) . This product is intended for research and analytical applications. Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM) . Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas[1][2].

• Target:

  Apoptosis; Autophagy; E1/E2/E3 Enzyme; MDM-2/p53; Reference Standards

• Related Pathways:

  Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

• Field of Research:

  Cancer

• Smiles:

  O=C (N1C (C2=C (C=C (C=C2) OC) OC (C) C) =N[C@H] ([C@H]1C3=CC=C (C=C3) Cl) C4=CC=C (C=C4) Cl) N5CC (NCC5) =O

• Molecular Formula:

  C30H30Cl2N4O4

• Molecular Weight:

  581.49

• References & Citations:

  [1]Crane EK, et al. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015 Aug 6;10 (8) :e0135101.|[2]Tovar C, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006 Feb 7;103 (6) :1888-93.|[3]M Ulrich, et al. Murine tumor models for the in vivo evaluation of natural compounds and their derivatives as new cancer therapeutics. München. 2016.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  675576-98-4