Nutlin-3a (Standard)

• Description :

  Nutlin-3a (Standard) is the analytical standard of Nutlin-3a (HY-10029) . This product is intended for research and analytical applications. Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM) . Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas[1][2].

• Target :

  Apoptosis; Autophagy; E1/E2/E3 Enzyme; MDM-2/p53; Reference Standards

• Related Pathways :

  Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer

• Smiles :

  O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=N[C@H]([C@H]1C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)N5CC(NCC5)=O

• Molecular Formula :

  C30H30Cl2N4O4

• Molecular Weight :

  581.49

• References & Citations :

  [1]Crane EK, et al. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015 Aug 6;10 (8) :e0135101.|[2]Tovar C, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006 Feb 7;103 (6) :1888-93.|[3]M Ulrich, et al. Murine tumor models for the in vivo evaluation of natural compounds and their derivatives as new cancer therapeutics. München. 2016.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [675576-98-4]