Nutlin-C1-amido-PEG4-C2-N3

Nutlin-C1-amido-PEG4-C2-N3

• Product Name Alternative: MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48
• UNSPSC Description: Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugates-48.html
• Purity: 99.19
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(CN(C(N1C(C2=CC=C(OC)C=C2OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]1C4=CC=C(Cl)C=C4)=O)CC5)N5CC(NCCOCCOCCOCCOCCN=[N+]=[N-])=O
• Molecular Weight: 883.83
• References & Citations: [1]Gu S, et al. PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery. Bioessays. 2018 Apr;40(4):e1700247.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen, away from moisture)
• Clinical Information: No Development Reported