Nutlin-3b

CAT: 0804-HY-15335-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15335-01Size:5 mg
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Description
Nutlin-3b, the inactive form of Nutlin-3 (HY-50696), is a p53/MDM2 inhibitor with an IC50 of 13.6 μM. Nutlin-3b is 150 times less potent in binding to MDM2 than Nutlin-3a (HY-10029) . Nutlin-3b is promising for research of cancers[1][2][3][4].
CAS Number
[675576-97-3]
UNSPSC
12352005
Hazard Statement
H302, H319, H332, H372, H400
Target
E1/E2/E3 Enzyme; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Nutlin-3b.html
Purity
98.78
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NCCN(C(N2[C@@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.49
Precautions
H302, H319, H332, H372, H400
References & Citations
[1]Vassilev LT, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science. 2004 Feb 6;303 (5659) :844-8.|[2]Müller CR, et al. Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A. Int J Cancer. 2007 Jul 1;121 (1) :199-205.|[3]Michaelis M, et al. Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3. Cancer Res. 2009 Jan 15;69 (2) :416-21. |[4]Zhang F, et al. MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport. Biochem Pharmacol. 2011 Jul 1;82 (1) :24-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS3605579-01Nutlin-3b
MBS386815-01Nutlin 3b
A11502-10Nutlin 3b 10mg
A11502-50Nutlin 3b 50mg
A11502-1Nutlin 3b 1mg
A11502-25Nutlin 3b 25mg
A11502-100Nutlin 3b 100mg
A11502-2Nutlin 3b 2mg
A11502-5Nutlin 3b 5mg
A11502-10mM-DNutlin 3b 10mM * 1mL in DMSO

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