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MG-T-19

CAT: 0804-HY-159884-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-159884-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MG-T-19 is an effective TIM-3 inhibitor that can suppress the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9. MG-T-19 can increase the production of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood mononuclear cells (PBMCs) from healthy donors, and enhance the ability of PBMCs to inhibit the proliferation of Kasumi-1 cells (an acute myelogenous leukemia cell line) [1].
CAS Number
328540-44-9
UNSPSC
12352101
Target
IFNAR; Tim3; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mg-t-19.html
Concentration
10mM
Purity
98.34
Solubility
DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=C(NC(C2=NN3C(N=C(C4=CC(Br)=CS4)C=C3C(F)(F)F)=C2Br)=O)C=C(Cl)C=C1
Molecular Formula
C18H8Br2ClF3N4O2S
Molecular Weight
596.60
References & Citations
[1]Abdel-Rahman S A, et al. Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints[J]. Science Advances, 2024, 10 (42) : eadq5540.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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