MG-3C

• Description :

  MG-3C is a potent matrix metalloproteinase 9 (MMP-9) inhibitor. MG-3C can selectively kill non-small-cell lung cancer (NSCLC) cells harboring the EGFR T790M mutation. MG-3C blocks the EGFR/STAT3 signaling pathway, inducing G2/M phase arrest, growth inhibition, and apoptosis of cancer cells. MG-3C is promising for research of lung cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; EGFR; MMP; STAT

• Related Pathways :

  Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=C2C(C(SC3=CC=C(/N=N\C4=CC=C(C(NCCCN5C(C=CC5=O)=O)=O)C=C4)C=C3)=CC=C26)=CC=C1)N(CCN(C)C)C6=O

• Molecular Formula :

  C36H32N6O5S

• Molecular Weight :

  660.74

• References & Citations :

  [1]Li L, et al. A novel MMP-9 inhibitor exhibits selective inhibition in non-small-cell lung cancer harboring EGFR T790M mutation by blocking EGFR/STAT3 signaling pathway. Bioorg Chem. 2025 Jun 1;159:108393.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MMP-9