STAT6-IN-3

• Description :

  STAT6-IN-3 is a phosphopeptide mimic targeting the SH2 domain of STAT6 and has a high affinity for STAT6 (IC50: 0.04 μM) . STAT6-IN-3 can be used in the research of inflammation such as asthma[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  STAT

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/stat6-in-3.html

• Concentration :

  10mM

• Purity :

  99.97

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(/C=C/C1=CC=C(C=C1)OP(O)(O)=O)N[C@H](C(N2CCC[C@H]2C(N(C3=CC=C(C=C3)I)C4=CC=CC=C4)=O)=O)C(C)(C)C

• Molecular Formula :

  C32H35IN3O7P

• Molecular Weight :

  731.51

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Mandal PK, et al. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25;58 (22) :8970-84.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [371919-80-1]