STAT6-IN-2

• Description:

  STAT6-IN-2 (Compound R-84) is a STAT6 inhibitor that can inhibit the tyrosine phosphorylation of STAT6. STAT6-IN-2 can also inhibit the secretion of eotaxin-3. STAT6-IN-2 can be used in the research of immune diseases and allergic inflammatory diseases such as asthma[1].

• UNSPSC:

  12352005

• Target:

  STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/stat6-in-2.html

• Purity:

  99.85

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CN1C(C2=CC(C(NCCC3=CC=CC=N3)=O)=NC(C(N[C@H](C)C(C)C)=O)=C2)=CC4=CC=CC=C41

• Molecular Formula:

  C28H31N5O2

• Molecular Weight:

  469.58

• References & Citations:

  [1]Zhou L, et.al. STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg Med Chem. 2012 Jan 15;20 (2) :750-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1355594-85-2]