STAT6-IN-9

• Description :

  STAT6-IN-9 (Compound 6) is a potent STAT6 inhibitor, with an EC50 value of 4 nM. STAT6-IN-9 efficiently blocks the STAT6 activation process mediated by the IL-13-IL-13 receptor/IL-4 receptor pathway. STAT6-IN-9 inhibits CCL17 secretion with an IC50 value of 4.6 nM. STAT6-IN-9 can be used in the research of various chronic inflammatory diseases mediated by STAT6, such as allergies, asthma, chronic obstructive pulmonary disease[1].

• UNSPSC :

  12352100

• Target :

  Interleukin Related; STAT

• Related Pathways :

  Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CN(C)C(C1=CN=C(C2=CC=C(N(N=C3C(NCC4=CC=C(NC(N5CCN(C)CC5)=O)C=C4)=O)CC)C3=C2)C=C1)=O

• Molecular Formula :

  C31H36N8O3

• Molecular Weight :

  568.67

• References & Citations :

  [1]CHOI, Chulho, et al. Nitrogen-Containing Heteroaryl Compounds for the Treatment of Chronic Diseases. WO 2025/133961 A1. World Intellectual Property Organization (WIPO) International Bureau. 26 June 2025.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  STAT6

• CAS Number :

  [3092076-15-5]