CP-96021

CAT: 0804-HY-163101-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-163101-01Size:1 mg
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Description
CP-96021 is a potent and orally available leukotriene D4 (LTD4 Ki=34 μM) / platelet activating factor (PAF Ki=37 μM) receptor antagonist. CP-96021 has antagonist capable of simultaneously targeting two different inflammatory mediators, LTD4 and PAF. CP-96021 shows high specificity for α1, α2, β, dopamine-2, adenosine 1, 5-HT1, H1, muscarine, μ opioid, and GABA receptors, all expressing IC50 values greater than 10 μM. CP-96021 can be used to study the pathogenesis of many inflammatory diseases such as asthma[1].
CAS Number
[139401-43-7]
UNSPSC
12352005
Target
Leukotriene Receptor; Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cp-96021.html
Purity
98.04
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=NC2=CN=CC=C2N1C3=CC=C(C=C3)OCC4=CC(/C=C/C5=NC6=CC(F)=CC=C6S5)=CC=C4
Molecular Formula
C29H21FN4OS
Molecular Weight
492.57
References & Citations
[1]Marfat A, et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4) /platelet activating factor (PAF) receptor antagonists[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5 (13) : 1377-1382.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTD4/CysLT1

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