CP-96021

• Description:

  CP-96021 is a potent and orally available leukotriene D4 (LTD4 Ki=34 μM) / platelet activating factor (PAF Ki=37 μM) receptor antagonist. CP-96021 has antagonist capable of simultaneously targeting two different inflammatory mediators, LTD4 and PAF. CP-96021 shows high specificity for α1, α2, β, dopamine-2, adenosine 1, 5-HT1, H1, muscarine, μ opioid, and GABA receptors, all expressing IC50 values greater than 10 μM. CP-96021 can be used to study the pathogenesis of many inflammatory diseases such as asthma[1].

• UNSPSC:

  12352005

• Target:

  Leukotriene Receptor; Platelet-activating Factor Receptor (PAFR)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cp-96021.html

• Purity:

  98.04

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  CC1=NC2=CN=CC=C2N1C3=CC=C (C=C3) OCC4=CC (/C=C/C5=NC6=CC (F) =CC=C6S5) =CC=C4

• Molecular Formula:

  C29H21FN4OS

• Molecular Weight:

  492.57

• References & Citations:

  [1]Marfat A, et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4) /platelet activating factor (PAF) receptor antagonists[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5 (13) : 1377-1382.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  LTD4/CysLT1

• CAS Number:

  139401-43-7