PF-8380

• Description:

  PF-8380 is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/PF-8380.html

• Purity:

  99.05

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (N1CCN (CC1) CCC (C2=CC (O3) =C (C=C2) NC3=O) =O) OCC4=CC (Cl) =CC (Cl) =C4

• Molecular Formula:

  C22H21Cl2N3O5

• Molecular Weight:

  478.33

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Gierse J, et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J Pharmacol Exp Ther. 2010 Jul;334 (1) :310-7.|[2]Bhave SR, et al. Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines. Front Oncol. 2013 Sep 17;3:236.|[3]Cao P, et al. Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis. J Clin Invest. 2017 Apr 3;127 (4) :1517-1530.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Autotaxin

• CAS Number:

  1144035-53-9