PF-4348235

• Description :

  β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA) . β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD) [1].

• Product Name Alternative :

  β2AR/M-receptor agonist-2

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor; mAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/pf-4348235.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H](C1=CC(NS(C)(=O)=O)=C(C=C1)O)CNCCCCCCCCCN(CC2)CCC2OC(NC3=C(C4=CC(Cl)=C(C=C4)O)C=CC=C3)=O

• Molecular Formula :

  C36H49ClN4O7S

• Molecular Weight :

  717.31

• References & Citations :

  [1]Laura Hilton, et al. Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. MedChemComm. 2011.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1017857-38-3]