PF-06842874

• Description :

  PF-06842874 is a CDK4/Cyclin D1 and CDK6/Cyclin D3 inhibitor (Ki values are 62 and 130 nM, respectively) . PF-06842874 can be used in the research of pulmonary arterial hypertension and cancer[1].

• UNSPSC :

  12352005

• Target :

  CDK

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer; Cardiovascular Disease

• Smiles :

  O=C1N(C2CCCC2)C3=CC(N[C@H]4[C@@H](COCC4)O)=NC=C3C(C)=C1C(C)=O

• Molecular Formula :

  C21H27N3O4

• Molecular Weight :

  385.46

• References & Citations :

  [1]Samit Kumar BhattacharyaI, et al. Anti-proliferative agents for treating pah. WO2020212865A1. Pfizer Inc. 2020-04-15.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK4; CDK6

• CAS Number :

  [2516247-98-4]