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DRF-2519 (free base)

CAT: 0804-HY-125716Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125716Size:1 Each
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Description
DRF-2519 (free base) is a dual activator of PPAR α and PPAR γ. DRF-2519 (free base) has antidiabetic and hypolipidemic activity[1].
CAS Number
194713-46-7
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/drf-2519-free-base.html
Smiles
O=C(N1)SC(CC2=CC=C(OCCN3COC4=CC=CC=C4C3=O)C=C2)C1=O
Molecular Formula
C20H18N2O5S
Molecular Weight
398.43
References & Citations
[1]Madhavan GR, et al. Dual PPAR-alpha and -gamma activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential. Bioorg Med Chem. 2006 Jan 15;14 (2) :584-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

Chemical Information

Drf 2519

antidiabetic and hypolipidemic; structure in first source

CAS Number194713-46-7
PubChem CID9908833
IUPAC Name5-[[4-[2-(4-oxo-2H-1,3-benzoxazin-3-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Molecular FormulaC20H18N2O5S
Molecular Weight398.4
XLogP3
Topological Polar Surface Area110
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity607
SMILES
C1N(C(=O)C2=CC=CC=C2O1)CCOC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
InChI
InChI=1S/C20H18N2O5S/c23-18-17(28-20(25)21-18)11-13-5-7-14(8-6-13)26-10-9-22-12-27-16-4-2-1-3-15(16)19(22)24/h1-8,17H,9-12H2,(H,21,23,25)
InChIKey
RFMNEXVCPAPDRA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Drf 2519
CAS: 194713-46-7
CID: 9908833
Formula: C20H18N2O5S
MW: 398.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight398.4
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass398.09364285
Monoisotopic Mass398.09364285
Topological Polar Surface Area110 Ų
Heavy Atom Count28
Formal Charge0
Complexity607
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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