DRF-2519 (free base)

CAT: 0804-HY-125716Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-125716Size:1 Each

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Description

DRF-2519 (free base) is a dual activator of PPAR α and PPAR γ. DRF-2519 (free base) has antidiabetic and hypolipidemic activity[1].

CAS Number

194713-46-7

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/drf-2519-free-base.html

Smiles

O=C(N1)SC(CC2=CC=C(OCCN3COC4=CC=CC=C4C3=O)C=C2)C1=O

Molecular Formula

C20H18N2O5S

Molecular Weight

398.43

References & Citations

[1]Madhavan GR, et al. Dual PPAR-alpha and -gamma activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential. Bioorg Med Chem. 2006 Jan 15;14 (2) :584-91.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Chemical Information

Drf 2519

antidiabetic and hypolipidemic; structure in first source

CAS Number	194713-46-7
PubChem CID	9908833
IUPAC Name	5-[[4-[2-(4-oxo-2H-1,3-benzoxazin-3-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Molecular Formula	C20H18N2O5S
Molecular Weight	398.4
XLogP	3
Topological Polar Surface Area	110
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Heavy Atom Count	28
Formal Charge	0
Complexity	607

SMILES

C1N(C(=O)C2=CC=CC=C2O1)CCOC3=CC=C(C=C3)CC4C(=O)NC(=O)S4

InChI

InChI=1S/C20H18N2O5S/c23-18-17(28-20(25)21-18)11-13-5-7-14(8-6-13)26-10-9-22-12-27-16-4-2-1-3-15(16)19(22)24/h1-8,17H,9-12H2,(H,21,23,25)

InChIKey

RFMNEXVCPAPDRA-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 194713-46-7

CID: 9908833

Formula: C20H18N2O5S

MW: 398.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	398.4
XLogP3	3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	398.09364285
Monoisotopic Mass	398.09364285
Topological Polar Surface Area	110 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	607
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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DRF-2519 (free base)

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