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(6R) -Taltobulin intermediate-9

CAT: 0804-HY-41071-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-41071-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(6R) -Taltobulin intermediate-9 is an intermediate in the synthesis of Taltobulin. Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/taltobulin-intermediate-9.html
Purity
95.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)[C@@H](/C=C(C)/C(OCC)=O)N(C([C@H](C(C)(C)C)NC([C@H](N(C(OC(C)(C)C)=O)C)C(C)(C)C1=CC=CC=C1)=O)=O)C
Molecular Formula
C34H55N3O6
Molecular Weight
601.82
Precautions
H302, H315, H319, H335
References & Citations
[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63 (8) :1838-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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