Taltobulin intermediate-7

• Description :

  Taltobulin intermediate-7 is an intermediate in the synthesis of Taltobulin (HY-15584) . Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/taltobulin-intermediate-7.html

• Purity :

  97.33

• Solubility :

  10 mM in DMSO

• Smiles :

  CC([C@@H](/C=C(C)/C(OCC)=O)N(C([C@@H](C(C)(C)C)NC(OC(C)(C)C)=O)=O)C)C

• Molecular Formula :

  C22H40N2O5

• Molecular Weight :

  412.56

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63 (8) :1838-45.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported