Taltobulin intermediate-12

• UNSPSC Description:

  Taltobulin intermediate-12 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

• Target Antigen:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/taltobulin-intermediate-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)(C1=CC=CC=C1)/C(C(OC)=O)=N/O

• Molecular Weight:

  221.25

• References & Citations:

  [1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported