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TRV-120027

CAT: 0804-HY-P2141-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2141-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages β-arrestins while blocking G-protein signaling[1]. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-β-arrestin-1-TRPC3-PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment[2].
CAS Number
1234510-46-3
Product Name Alternative
TRV027
UNSPSC
12352209
Target
Angiotensin Receptor; Arrestin
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/trv-120027.html
Purity
98.11
Solubility
H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@H](C(O)=O)NC([C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)=O)=O)=O)CCC1)=O
Molecular Formula
C43H67N13O10
Molecular Weight
926.07
References & Citations
[1]Boerrigter G, et al. TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure.Circ Heart Fail. 2012 Sep 1;5 (5) :627-34. Epub 2012 Aug 13.|[2]Liu CH, et al. Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.Nat Commun. 2017 Feb 9;8:14335.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Phase 2
Isoform
Arrestin-2/β-Arrestin 1; AT1 Receptor
Citation 01
Eur J Pharmacol. 2023 Jul 15:951:175780.|J Am Heart Assoc. 2022 Feb 15;11 (4) :e022070.|University of Medicine Berlin. 2023 Mar.

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