CVT-12012

• Description:

  CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.

• UNSPSC:

  12352005

• Target:

  Stearoyl-CoA Desaturase (SCD)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/CVT-12012.html

• Purity:

  99.58

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C (NCCN1C (C (C) =NC2=C1C=C (NCC3=CC=CC (C (F) (F) F) =C3) C=C2) =O) CO

• Molecular Formula:

  C21H21F3N4O3

• Molecular Weight:

  434.41

• References & Citations:

  [1]Koltun DO, et al. Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19 (15) :4070-4.|[2]Atkinson KA, et al. N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21 (6) :1621-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1018675-35-8