AGI-12026

• Description:

  AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma[1].

• Product Name Alternative:

  AGI-026

• UNSPSC:

  12352005

• Target:

  Isocitrate Dehydrogenase (IDH)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/agi-12026.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(F)(F)C1=CC=CC(C2=NC(NC(C)C)=NC(NC3=CC(C(F)(F)F)=NC=C3)=N2)=N1

• Molecular Formula:

  C18H15F6N7

• Molecular Weight:

  443.35

• References & Citations:

  [1]Konteatis Z, et al. Vorasidenib (AG-881) : A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma. ACS Med Chem Lett. 2020;11 (2) :101-107.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IDH1

• CAS Number:

  [1446501-77-4]