AGI-12026

• Description :

  AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma[1].

• Product Name Alternative :

  AGI-026

• UNSPSC :

  12352005

• Target :

  Isocitrate Dehydrogenase (IDH)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/agi-12026.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC(F)(F)C1=CC=CC(C2=NC(NC(C)C)=NC(NC3=CC(C(F)(F)F)=NC=C3)=N2)=N1

• Molecular Formula :

  C18H15F6N7

• Molecular Weight :

  443.35

• References & Citations :

  [1]Konteatis Z, et al. Vorasidenib (AG-881) : A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma. ACS Med Chem Lett. 2020;11 (2) :101-107.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IDH1

• CAS Number :

  [1446501-77-4]