BIBF 1202

CAT: 0804-HY-15992-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15992-01Size:5 mg
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Description
BIBF 1202 is the carboxylate metabolite of Nintedanib (HY-50904) which inhibits VEGFR2 kinase with an IC50 of 62 nM.
CAS Number
[894783-71-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BIBF-1202.html
Purity
99.82
Solubility
DMSO : ≥ 45 mg/mL
Smiles
O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)O
Molecular Formula
C30H31N5O4
Molecular Weight
525.60
Precautions
H302, H315, H319, H335
References & Citations
[2]Stopfer P, et al. Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica. 2011 Apr;41 (4) :297-311.|[1]Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumorefficacy. Cancer Res. 2008 Jun 15;68 (12) :4774-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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A21006-1BIBF 1202 1mg
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A21006-25BIBF 1202 25mg
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