(4-NH2)-Exatecan-d5

• UNSPSC Description:

  (4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan[1]. (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[2].

• Target Antigen:

  ADC Cytotoxin; Isotope-Labeled Compounds; Topoisomerase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles:

  O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5N)=CC6=C1COC([C@]6(O)C([2H])([2H])C([2H])([2H])[2H])=O

• Molecular Weight:

  408.46

• References & Citations:

  [1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported