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Exatecan-d5 (mesylate)

CAT: 0804-HY-13631AS-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13631AS-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Exatecan-d5 (DX8951f-d5) mesylate is deuterium labeled Exatecan mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research[1].
CAS Number
2819276-88-3
Product Name Alternative
DX8951f-d5; Deuterated labeled Exatecan (mesylate)
UNSPSC
12352005
Hazard Statement
H300, H340, H360
Target
ADC Payload; Isotope-Labeled Compounds; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.83
Solubility
DMSO : 11.11 mg/mL (ultrasonic) |H2O : 1mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=S(C)(O)=O.O=C1[C@](O)(C(C([2H])([2H])[2H])([2H])[2H])C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O
Molecular Formula
C25H21D5FN3O7S
Molecular Weight
536.58
Precautions
H300, H340, H360
References & Citations
[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Camptothecins

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