(R)-(4-NH2)-Exatecan

(R)-(4-NH2)-Exatecan

• UNSPSC Description: (R)-(4-NH2)-Exatecan is the R enantiomer of (4-NH2)-Exatecan (Compound A). (R)-(4-NH2)-Exatecan, a topoisomerase inhibitor, is a derivative of Exatecan. (R)-(4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
• Target Antigen: ADC Cytotoxin; Topoisomerase
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/r-4-nh2-exatecan.html
• Smiles: NC1=CC=C2C3=C1CCCC3=C4CN5C(C4=N2)=CC([C@@](O)6CC)=C(C5=O)COC6=O
• Molecular Weight: 403.43
• References & Citations: [1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported