YM-543

• Description :

  YM-543 is a selective SGLT2 inhibitor that effectively reduces hyperglycemia in type 2 diabetic mice through increased urinary glucose excretion. YM-543 demonstrates potent inhibition of both mouse and human SGLT2 activities at nanomolar concentrations. YM-543, when administered orally, significantly improves glucose tolerance in diabetic models and sustains its effects for over 12 hours. YM-543, in combination with other antidiabetic agents like rosiglitazone or metformin, enhances the therapeutic effects on diabetic symptoms. YM-543 does not affect blood glucose levels in normal mice, indicating its specificity for diabetic conditions.

• CAS Number :

  [1610007-47-0]

• UNSPSC :

  12352005

• Target :

  SGLT

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/ym-543.html

• Smiles :

  C[N+](C)(C)CC[O-].O[C@H]1[C@H](C2=CC(CC3=CC4=CC=CC=CC4=C3)=CC=C2O)O[C@@H]([C@H]([C@@H]1O)O)CO

• Molecular Formula :

  C28H37NO7

• Molecular Weight :

  499.60

• References & Citations :

  [1]Pharmacological Characterization of YM543, a Newly Synthesized, Orally Active SGLT2 Selective Inhibitor

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  SGLT2