YM-543

• Description:

  YM-543 is a selective SGLT2 inhibitor that effectively reduces hyperglycemia in type 2 diabetic mice through increased urinary glucose excretion. YM-543 demonstrates potent inhibition of both mouse and human SGLT2 activities at nanomolar concentrations. YM-543, when administered orally, significantly improves glucose tolerance in diabetic models and sustains its effects for over 12 hours. YM-543, in combination with other antidiabetic agents like rosiglitazone or metformin, enhances the therapeutic effects on diabetic symptoms. YM-543 does not affect blood glucose levels in normal mice, indicating its specificity for diabetic conditions.

• UNSPSC:

  12352005

• Target:

  SGLT

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ym-543.html

• Smiles:

  C[N+] (C) (C) CC[O-].O[C@H]1[C@H] (C2=CC (CC3=CC4=CC=CC=CC4=C3) =CC=C2O) O[C@@H] ([C@H] ([C@@H]1O) O) CO

• Molecular Formula:

  C28H37NO7

• Molecular Weight:

  499.60

• References & Citations:

  [1]Pharmacological Characterization of YM543, a Newly Synthesized, Orally Active SGLT2 Selective Inhibitor

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  SGLT2

• CAS Number:

  1610007-47-0